denis
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Posts: 1,833
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Post by denis on Jul 11, 2022 11:38:16 GMT
OK, thanks m8. Modern Medical Research Part 2Tips For Health Research online (In the "Tips", DuckDuckGo and Brave are mentioned. I'd add Start Page to that. I use DDG.) Why not use Google? Glad you asked. HERE'S why. I use the Tor web browser. As for email, prontonmail is highly recommended. Protonmail
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denis
Caneguru
Posts: 1,833
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Post by denis on Jul 14, 2022 7:11:33 GMT
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denis
Caneguru
Posts: 1,833
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Post by denis on Jul 14, 2022 7:29:49 GMT
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Post by mr potatohead on Jul 17, 2022 15:35:11 GMT
As I was reviewing macky's isometric Member Workout Log, I saw a post by moxohol on the first page that mentioned BPC-157 as recommended to heal fascia, as in tears due to hernia, as well as helping to heal other tissue. So, I did a net search and found THIS which also mentions its effectiveness against parasites (/"viruses"), not just in humans, but also the Nosema ceranae parasite that threatens bees. The one negative (I noticed) about BPC-157 that is mentioned in the article is that it may promote tumor growth. ...............?? If you have any experience with this, I'd like to hear about it.
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Post by mr potatohead on Jul 17, 2022 18:06:43 GMT
From further research, it seems that BPC-157 is also Collagen Peptides (Collagen Hydrosolate), and that bone broth contains this in addition to other beneficial nutrients. So, maybe just drinking good quality bone broth or using it in cooking would work fine to obtain BPC-157 along with other nutrients that would work together as whole food?
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brothersteve
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He ain't heavy, he's my brother
Posts: 2,267
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Post by brothersteve on Jul 18, 2022 11:10:50 GMT
"...Collagen Peptides..." .... paging Moxohol on this subject.
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Post by mr potatohead on Jul 28, 2022 14:43:15 GMT
While researching White Willow Bark, I came upon some more info about Wormwood / Artemisia Absinthium (not that White Willow Bark and Wormwood are related). What I discovered is that, it appears that Wormwood and Yarrow are both in the Asteraceae family and wild Aster was used by the N.A. Indians for both, food and medicine. Just thought that it was interesting.
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moxohol
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Biohacker
Quod tu es, ego fui. Quod ego sum, tu eris.
Posts: 3,378
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Post by moxohol on Aug 3, 2022 6:37:45 GMT
As I was reviewing macky's isometric Member Workout Log, I saw a post by moxohol on the first page that mentioned BPC-157 as recommended to heal fascia, as in tears due to hernia, as well as helping to heal other tissue. So, I did a net search and found THIS which also mentions its effectiveness against parasites (/"viruses"), not just in humans, but also the Nosema ceranae parasite that threatens bees. The one negative (I noticed) about BPC-157 that is mentioned in the article is that it may promote tumor growth. ...............?? If you have any experience with this, I'd like to hear about it. I had a car accident in 2014 here in Egypt. I suffered multiple limb fractures including the spine. I also had embolisms due to said fractures. My medical consultant put me on various bioregulators, gelatin (BLECCH), & Phage Therapy for osteomyelitis. BPC-157, TB-500, & Osteogenic Growth Peptide were my bioregulator mainstays & they collectively precluded the need of an laminectomy & femur pins/rods among other various concurrent ailments.
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moxohol
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Quod tu es, ego fui. Quod ego sum, tu eris.
Posts: 3,378
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Post by moxohol on Aug 3, 2022 7:19:15 GMT
"...Collagen Peptides..." .... paging Moxohol on this subject. "YOU asked for it. You got it - Toyota!" ============ Faster than a overclocked CPU. More powerful than a ASUS ROG Strix X570-F motherboard. Able to surf pages in a single click. Look! Up in the sky?? It's a nerd? (he's a pain) It's MOXOHOL! Yes, it's moxohol - strange visitor from another gateway hub with knowledge far beyond those of mortal hens. Moxohol - who can change minds with superlative logic, bend wills with persuasive fallacies, & who disguised as a pseudo-prodigy, mild-mannered cybergeek working as a self-employed freelancer, fights a neverending battle for Truth, Arguments, and the Iconoclastic Way. REF: 1) www.genomebc.ca/wp-content/uploads/2018/03/GBC_Microbiome_final2018.pdfAre Peptides the Epigenetic Secret to the Fountain of Youth? | Ultiself Blog ultiself.com/blog/are-peptides-the-epigenetic-secret-to-the-fountain-of-youthPentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts www.ncbi.nlm.nih.gov/pmc/articles/PMC6271067/
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TexasRanger
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A little here, a little there...
Posts: 2,223
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Post by TexasRanger on Aug 3, 2022 11:35:05 GMT
Revelation: I stopped wasting $$$$ on supplements. After weighing the claims vs. the science, I realized the best thing for the body for healing is clean food and fasting.
Supplements are processed, highly concentrated products and some have toxic affects.
The world's longest-lived societies don't rely on supplements, etc. Food is their stable. And as author Michael Pollan writes:
"Eat food. Not too much. Mostly plants."
Add the findings of researchers like Dr. Valter Longo -- fast. Not starvation, but give your body's autophagy processes a window to work, your hormones (HGH, glucagon) the chance to work their magic. There's a great interview with Longo who is asked about claims that this or that supplement will extend life, provide certain benefits. His answer? There's no long term research, there are no studies validating any of the alleged benefits. But as Longo said in the BBC documentary "Eat, Fast and Live Longer" he can't find a pill that does as much for the body as fasting provides.
The evidence is there: lower your protein, your mTOR is lowered and your lifespan improves. Lower your processed foods -- fats, protein, carbs -- and increase your whole foods? Your metabolic system works better, less nutrients are stored as fat. (ref Dr. David Ludwig, MD/PhD, Harvard University/School of Endocrinology)
Just my opinion, folks. N = 1 But, as the handful of supplements I was taking ran out, I haven't replaced them and have felt fine. Fasting includes Time Restricted Eating and days where I'm doing 16:8.
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moxohol
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Quod tu es, ego fui. Quod ego sum, tu eris.
Posts: 3,378
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Post by moxohol on Aug 3, 2022 11:38:17 GMT
Revelation: I stopped wasting $$$$ on supplements. After weighing the claims vs. the science, I realized the best thing for the body for healing is clean food and fasting. Supplements are processed, highly concentrated products and some have toxic affects. The world's longest-lived societies don't rely on supplements, etc. Food is their stable. And as author Michael Pollan writes: "Eat food. Not too much. Mostly plants."
Add the findings of researchers like Dr. Valter Longo -- fast. Not starvation, but give your body's autophagy processes a window to work, your hormones (HGH, glucagon) the chance to work their magic. There's a great interview with Longo who is asked about claims that this or that supplement will extend life, provide certain benefits. His answer? There's no long term research, there are no studies validating any of the alleged benefits. But as Longo said in the BBC documentary "Eat, Fast and Live Longer" he can't find a pill that does as much for the body as fasting provides. The evidence is there: lower your protein, your mTOR is lowered and your lifespan improves. Lower your processed foods -- fats, protein, carbs -- and increase your whole foods? Your metabolic system works better, less nutrients are stored as fat. (ref Dr. David Ludwig, MD/PhD, Harvard University/School of Endocrinology) Just my opinion, folks. N = 1 But, as the handful of supplements I was taking ran out, I haven't replaced them and have felt fine. Fasting includes Time Restricted Eating and days where I'm doing 16:8. Aspirin(1) enhances autophagy & wheat germ repairs the Autophagic System(2,3,4). REF: 1) Autophagy-mediated metabolic effects of aspirin | Cell Death Discovery www.nature.com/articles/s41420-020-00365-02) Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? www.ncbi.nlm.nih.gov/pmc/articles/PMC6287690/3) Frontiers | Polyamines in Food www.frontiersin.org/articles/10.3389/fnut.2019.00108/full4) The anti-aging drug from the own body: Spermidine innovationorigins.com/en/the-anti-aging-drug-from-your-own-body-spermidine/
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TexasRanger
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A little here, a little there...
Posts: 2,223
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Post by TexasRanger on Aug 3, 2022 14:43:09 GMT
Familiar with spermidine -- have heard several podcasts on it. Very, very new 'discovery', no long term studies or validation of the benefits. Also, there is a conflict of interst in the NIH article: it was funded by the supplement manufacturer. Another reference notes spermidine "might": "suggesting that spermidine-treatment might be able to attenuate the normally occurring age-induced increase in glucose uptake." link.springer.com/article/10.1007/s11357-020-00310-0 Same article? "Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length" However, if you look at the research further down the page it shows very minor benefits from the spermidine based on the graphs. What is proven to increase telomore length? Fasting (Longo, Estevez, et al), a whole foods diet with lower animal protein, exercise and sleep. www.ornish.com/wp-content/uploads/Lancet_Lifestyle-changes-lengthen-telomeres.pdf" rel="nofollow" target="_blank">pubmed.ncbi.nlm.nih.gov/24051140/ www.ornish.com/wp-content/uploads/Lancet_Lifestyle-changes-lengthen-telomeres.pdfThere's weak evidence on aspirin as claimed per several researchers. Please note that even with the reference you provide, the authors state: "Aspirin induces autophagy through the inhibition of EP30014,15,16. However, inhibition of EP300 with its pharmacological antagonist C646 is not sufficient to induce protein deacetylation in cultured cells, contrasting with salicylate that significantly reduces acetylation (Fig. 3a)." And "We and others have previously demonstrated that fasting or other caloric restriction mimetics than aspirin (such as spermidine and resveratrol) also induce a broad deacetylation of multiple proteins involved in the regulation or execution of autophagy34. Hence, it appears that a multipronged (rather than single-molecule) deacetylation pathway explains the effects of caloric restriction mimetics with respect to autophagy induction." The claims regarding resveratrol appear to be fraudulent. The US Justice Department is investigating an individual whose papers have been used by individuals such as David Sinclair to validate the use of this supplement and when I'd read about the potential fraud three or four months ago (the reference was sent to me by an MD who called "BS" on some of Sinclair's claims regarding the supplement), also found similar findings on NAD via NMN -- which Sinclair is selling at a VERY high price. There's a podcast by a Dr. Joel Kahn who cites potential health issues (not to mention impact to your wallet) with using NMN as Sinclair advises. And Longo was on a recent Rich Roll podcast criticizing claims about both resveratrol and NMN, citing zero long term studies and asking "how many centurians or people living healthy lives into their 90s use any of these products." Again, just my feedback because for me? Fasting is natural, something mammals have experienced during our ancestral evolution throughout times of food shortages. With humans? It has been a religious practice for some, cleansing for others. It doesn't cost money (so there's no money involved for supplement or drug manufacturers), it has been studied for over 100 years and there are no side affects like aspirin (damage to the lining of the stomach) or exorbitant $$$ for supplements that really aren't proven (again, my opinion based on what I've read).
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moxohol
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Quod tu es, ego fui. Quod ego sum, tu eris.
Posts: 3,378
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Post by moxohol on Aug 3, 2022 17:06:23 GMT
Familiar with spermidine -- have heard several podcasts on it. Very, very new 'discovery', no long term studies or validation of the benefits..................................... it has been studied for over 100 years and there are no side affects like aspirin (damage to the lining of the stomach) or exorbitant $$$ for supplements that really aren't proven (again, my opinion based on what I've read). Spermidine has a well established attribute of inducting autophagy. U can easily use a search engine & find a plethora of legit studies about Spermidine & autophagy not done in China & without any conflict of interest. My bad. ===================== Aspirin must have a significant NM level to significantly inhibit CP300. As I understand it, u need a 1 mM concentration of salicylate to see any degree of EP300 inhibition, and that level isn’t reached unless someone is taking a lot of aspirin. 3g is the minimum. However, if taken with Metformin that dosage is drastically reduced. One aspirin. Despite this, aspirin is a valid autophagy inductor. "....Here, we show that aspirin or its active metabolite salicylate induce autophagy by virtue of their capacity to inhibit the acetyltransferase activity of EP300. While salicylate readily stimulates autophagic flux in control cells, it fails to further increase autophagy levels in EP300-deficient cells, as well as in cells in which endogenous EP300 has been replaced by salicylate-resistant EP300 mutants. Accordingly, the pro-autophagic activity of aspirin and salicylate on the nematode Caenorhabditis elegans is lost when the expression of the EP300 ortholog cpb-1 is reduced. Altogether, these findings identify aspirin as an evolutionary conserved CRM...."(1) REF: 1) Aspirin Recapitulates Features of Caloric Restriction - ScienceDirect www.sciencedirect.com/science/article/pii/S221112471830192XAutophagy-mediated metabolic effects of aspirin | Cell Death Discovery www.nature.com/articles/s41420-020-00365-0
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MBS
Caneguru
Lean, lithe and feral
Posts: 1,302
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Post by MBS on Aug 4, 2022 3:24:24 GMT
Familiar with spermidine -- have heard several podcasts on it. Very, very new 'discovery', no long term studies or validation of the benefits. Also, there is a conflict of interst in the NIH article: it was funded by the supplement manufacturer. Another reference notes spermidine "might": "suggesting that spermidine-treatment might be able to attenuate the normally occurring age-induced increase in glucose uptake." link.springer.com/article/10.1007/s11357-020-00310-0 Same article? "Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length" However, if you look at the research further down the page it shows very minor benefits from the spermidine based on the graphs. What is proven to increase telomore length? Fasting (Longo, Estevez, et al), a whole foods diet with lower animal protein, exercise and sleep. www.ornish.com/wp-content/uploads/Lancet_Lifestyle-changes-lengthen-telomeres.pdf" rel="nofollow" target="_blank">pubmed.ncbi.nlm.nih.gov/24051140/ www.ornish.com/wp-content/uploads/Lancet_Lifestyle-changes-lengthen-telomeres.pdfThere's weak evidence on aspirin as claimed per several researchers. Please note that even with the reference you provide, the authors state: "Aspirin induces autophagy through the inhibition of EP30014,15,16. However, inhibition of EP300 with its pharmacological antagonist C646 is not sufficient to induce protein deacetylation in cultured cells, contrasting with salicylate that significantly reduces acetylation (Fig. 3a)." And "We and others have previously demonstrated that fasting or other caloric restriction mimetics than aspirin (such as spermidine and resveratrol) also induce a broad deacetylation of multiple proteins involved in the regulation or execution of autophagy34. Hence, it appears that a multipronged (rather than single-molecule) deacetylation pathway explains the effects of caloric restriction mimetics with respect to autophagy induction." The claims regarding resveratrol appear to be fraudulent. The US Justice Department is investigating an individual whose papers have been used by individuals such as David Sinclair to validate the use of this supplement and when I'd read about the potential fraud three or four months ago (the reference was sent to me by an MD who called "BS" on some of Sinclair's claims regarding the supplement), also found similar findings on NAD via NMN -- which Sinclair is selling at a VERY high price. There's a podcast by a Dr. Joel Kahn who cites potential health issues (not to mention impact to your wallet) with using NMN as Sinclair advises. And Longo was on a recent Rich Roll podcast criticizing claims about both resveratrol and NMN, citing zero long term studies and asking "how many centurians or people living healthy lives into their 90s use any of these products." Again, just my feedback because for me? Fasting is natural, something mammals have experienced during our ancestral evolution throughout times of food shortages. With humans? It has been a religious practice for some, cleansing for others. It doesn't cost money (so there's no money involved for supplement or drug manufacturers), it has been studied for over 100 years and there are no side affects like aspirin (damage to the lining of the stomach) or exorbitant $$$ for supplements that really aren't proven (again, my opinion based on what I've read). I allowed myself to be “ marketed” by Sinclair, and ended up buying some NMN and resveratrol. Didnt buy it from him, but it was still expensive. Took that combo for about five months, and noticed nothing. I’ve felt more immediate benefits from just skipping a meal or two, than any supplement I’ve ever taken. TR, what do you think of Dr Peter Attia? He once said exercise, properly done is 5x better for extending health span than any supplement, and felt the only people benefiting from NMN, resveratrol, etc, are the people that sell it. You nailed it: eat clean food, and fast ( or at least skip meals occasionally).
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Post by mr potatohead on Aug 4, 2022 7:48:33 GMT
Supplementation is beneficial, but the first thing to consider is diet. Eating a clean diet is #1 priority. Fasting, exercise, fresh air, clean water, etc, are also part of healthy living, of course. "Eat REAL food, not too much, mostly plants." Once diet is addressed, then is the time to investigate supplementation. Clean diet, along with appropriate supplementation according to individual need, with quality supplements, is certainly beneficial. Even Dr Valter Longo recommends a quality multi. Dr Joel Fuhrman on supplementation and who says that multi-vitamins (e.g. "drug store, conventional multis") are junk. Quality, targeted supplementation for the individual, is the way to go. My own opinion (but not my own, original, idea), which I've posted so many times, is that the minimum supplementation, which can benefit anyone including those on a crappy diet, is a quality liquid mineral supplement.
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