TexasRanger
Caneguru
A little here, a little there...
Posts: 2,223 
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Post by TexasRanger on Jan 21, 2024 1:25:09 GMT
Mentioned a few months ago more focus on VO2, less on "strength". The more I learn what a joke a human being's strength capabilities are vs. apes and other animals, beyond staying strong for normal day-to-day activities, the rest of the hype is a big question regarding "why"? Even doing things like Chimp Walks -- what is the point? Doubt our ancestors ever wasted time and joint health on things like that. Anyway, while running re-listening to podcasts with people like David Sinclair, PhD -- he and his team discovered the factors key to actually reversing aging, Longo, etc. Sinclair dives hard core into the science especially with interviewers like Attia and Dr Rhonda Patrick but a few key points I re-read in his book and papers on the web: - Smoking is horrible for longevity. He admits it is obvious, but apparently not for those who still partake. - Diet. High protein diets, saturated fats, processed and fried foods (sugars/white carbs/hydrogenated oils) and eating too often/too many calories. They also note protein drives mTOR up which negatively affects AMPK, a protein kinease generated by sirtuins and is highly critical to our health, metabolism and longevity. Science believes fasting, low protein and vegetarian diets may be a big factor in longevity since there's lower mTOR stimulation. SFAs have other negative affects which impact our longevity and -- like junk foods -- drive insulin resistance. Lots of more detailed charts on the web, but this is a pretty clear representation of how mTOR affects aging and disease (eg the proliferation of cancer cells, etc.) ![]()  ![]() |
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Post by thag on Jan 21, 2024 3:05:27 GMT
Mentioned a few months ago more focus on VO2, less on "strength". The more I learn what a joke a human being's strength capabilities are vs. apes and other animals, beyond staying strong for normal day-to-day activities, the rest of the hype is a big question regarding "why"? Even doing things like Chimp Walks -- what is the point? Doubt our ancestors ever wasted time and joint health on things like that. Anyway, while running re-listening to podcasts with people like David Sinclair, PhD -- he and his team discovered the factors key to actually reversing aging, Longo, etc. Sinclair dives hard core into the science especially with interviewers like Attia and Dr Rhonda Patrick but a few key points I re-read in his book and papers on the web: - Smoking is horrible for longevity. He admits it is obvious, but apparently not for those who still partake. - Diet. High protein diets, saturated fats, processed and fried foods (sugars/white carbs/hydrogenated oils) and eating too often/too many calories. They also note protein drives mTOR up which negatively affects AMPK, a protein kinease generated by sirtuins and is highly critical to our health, metabolism and longevity. Science believes fasting, low protein and vegetarian diets may be a big factor in longevity since there's lower mTOR stimulation. SFAs have other negative affects which impact our longevity and -- like junk foods -- drive insulin resistance. Lots of more detailed charts on the web, but this is a pretty clear representation of how mTOR affects aging and disease (eg the proliferation of cancer cells, etc.) ![]() ![]() Makes sense, do those scientists recommend a certain type of fasting? I remember Attia in Outlive book recommended weighted rucksack walking and noted on page 220 “Eventually, I will reach the point at which I just can’t produce any more energy via oxygen-dependent pathways, and I’ll be forced to switch over to less efficient, less sustainable ways of producing power, such as those used in sprinting.” |
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TexasRanger
Caneguru
A little here, a little there...
Posts: 2,223
|
Post by TexasRanger on Jan 21, 2024 4:29:28 GMT
Makes sense, do those scientists recommend a certain type of fasting? I remember Attia in Outlive book recommended weighted rucksack walking and noted on page 220 “Eventually, I will reach the point at which I just can’t produce any more energy via oxygen-dependent pathways, and I’ll be forced to switch over to less efficient, less sustainable ways of producing power, such as those used in sprinting." Yessir, but Attia does note in his book and multiple videos that VO2 max is the key factor in longevity and then describes Zone 2 and 5 training. I'm not a scientist, but I partially agreed with Attia's explanation and also believe metabolic health is part of it not just training. In one of his interviews w/ one of the experts in this science (not the PhD cited in the book) he notes VO2 max is a combination of multiple factors not just training LBM, optimal weight, general health, etc. Link: How does VO2 max correlate with longevity?Sorry...went down a bunny hole. As for fasting, depends on the research and researcher. - "The" godfather of IF in the US going back to the early 1990s is no doubt Dr. Mark Mattson of Johns Hopkins University. He's a 16:8 type, believe he's very low protein. His prime work has been in the area of nuerological disease. He got into fasting by accident as Mattson just started skipping breakfast as he was cycling and running in the morning and the food gave him acid reflux while training. Can't recall when he start doing work on IF and human disease, but believe it was in the 1990s. - Longo advocates Time Restricted Eating and works with Satchin Panda via research which supports keeping your eating window less than 12 hours. But, Longo does want you to eat breakfast -- he cites research showing a morning meal is important but have a very light lunch if hungry. Several cardiologists also prefer morning meals vs fasting so so your insulin response is more level throughout the day. You may also recall Longo's Fasting Mimicking Diet which you can do with ProLon (quite expensive) or find menus on line. - Sinclair likes 18:6, but admits on his podcast he is now OMAD..a bit confusing as he does state elsewhere that he has a very small amount of yogurt in the morning to take his supplements (reveratrol, D3, etc.). - Dr. Bert Herring, MD -- cancer researcher at the NIH likes 19:5. Stumbled on to the idea when, like Mattson, he started skipping meals and found he was losing bodyfat, feeling better and posted his Fast-5 program for free in 2005. Herring applied his research to his own medical research. www.bertherring.com/Common amongst all of them is no snacking, period. Sinclair states a key recommendation is simple, "Eat less often". Fasting advocate Dr. Jason Fung calls the 5 - 6 meal/day approach of Body for Life/bodybuilding "stupid" -- goes so far as to saying all the snacks kids are getting is ruining their health and we can see the disasterous result with adults. NOTE: There are also many who say fasting really isn't necessary if you're eating right. Clean diets via vegetarians, low protein diets and vegans will result in low mTOR/low IGF-1/low insulin. So, lots of good ideas from the researchers and of course extended fasts should be done with caution or under supervision. Gives options to find what works best for the individual if interested. |
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Post by thag on Jan 21, 2024 10:58:55 GMT
Makes sense, do those scientists recommend a certain type of fasting? I remember Attia in Outlive book recommended weighted rucksack walking and noted on page 220 “Eventually, I will reach the point at which I just can’t produce any more energy via oxygen-dependent pathways, and I’ll be forced to switch over to less efficient, less sustainable ways of producing power, such as those used in sprinting." Yessir, but Attia does note in his book and multiple videos that VO2 max is the key factor in longevity and then describes Zone 2 and 5 training. I'm not a scientist, but I partially agreed with Attia's explanation and also believe metabolic health is part of it not just training. In one of his interviews w/ one of the experts in this science (not the PhD cited in the book) he notes VO2 max is a combination of multiple factors not just training LBM, optimal weight, general health, etc. Link: How does VO2 max correlate with longevity?Sorry...went down a bunny hole. As for fasting, depends on the research and researcher. - "The" godfather of IF in the US going back to the early 1990s is no doubt Dr. Mark Mattson of Johns Hopkins University. He's a 16:8 type, believe he's very low protein. His prime work has been in the area of nuerological disease. He got into fasting by accident as Mattson just started skipping breakfast as he was cycling and running in the morning and the food gave him acid reflux while training. Can't recall when he start doing work on IF and human disease, but believe it was in the 1990s. - Longo advocates Time Restricted Eating and works with Satchin Panda via research which supports keeping your eating window less than 12 hours. But, Longo does want you to eat breakfast -- he cites research showing a morning meal is important but have a very light lunch if hungry. Several cardiologists also prefer morning meals vs fasting so so your insulin response is more level throughout the day. You may also recall Longo's Fasting Mimicking Diet which you can do with ProLon (quite expensive) or find menus on line. - Sinclair likes 18:6, but admits on his podcast he is now OMAD..a bit confusing as he does state elsewhere that he has a very small amount of yogurt in the morning to take his supplements (reveratrol, D3, etc.). - Dr. Bert Herring, MD -- cancer researcher at the NIH likes 19:5. Stumbled on to the idea when, like Mattson, he started skipping meals and found he was losing bodyfat, feeling better and posted his Fast-5 program for free in 2005. Herring applied his research to his own medical research. www.bertherring.com/Common amongst all of them is no snacking, period. Sinclair states a key recommendation is simple, "Eat less often". Fasting advocate Dr. Jason Fung calls the 5 - 6 meal/day approach of Body for Life/bodybuilding "stupid" -- goes so far as to saying all the snacks kids are getting is ruining their health and we can see the disasterous result with adults. NOTE: There are also many who say fasting really isn't necessary if you're eating right. Clean diets via vegetarians, low protein diets and vegans will result in low mTOR/low IGF-1/low insulin. So, lots of good ideas from the researchers and of course extended fasts should be done with caution or under supervision. Gives options to find what works best for the individual if interested. Thank you Sir. Snacking reminds me of cows grazing through out the day and I don’t believe we look at them as longevity role models. |
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Post by thag on Feb 17, 2024 23:09:36 GMT
Mark Mattson in The Intermittent Fasting Revolution on page 38 fasting triggers metabolism switch from glucose to ketones. He discusses several health benefits to include improvements in blood pressure and studies have shown how intermittent fasting reduces inflammation and disease to include obesity, cancer, inflammatory bowel disease, stroke, and multiple sclerosis (page 59). I also thought it was interesting on page 81 where he discusses how cancer cells cannot use ketones for energy which reduces energy supply for cancer cells so the side effects on normal cells may be reduced during cancer treatments. He mentions billions and billions have been spent on new drugs and other treatments.
Sorry I haven’t made it past that but I’m enjoying the book and information I’m reading.
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